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Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables
which promotes a beneficial estrogen metabolism in both women
and men.
Pure Diindolylmethane is insoluble and poorly
absorbed by the human body. Michael A. Zeligs, M.D. was awarded
a U.S. Patent for absorption-enhanced microencapsulated Diindolylmethane,
making it the only formulation shown in humans to improve
estrogen metabolism.
Much of the research summarized here used
Dr. Zeligs' microencapsulated, absorption-enhanced formulation of DIM.
*All published clinical studies have ONLY
used the patented microencapsulated formulation of DIM.
The following definition of diindolylmethane was taken from
the National Cancer Institute:
diindolylmethane
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: BioResponse DIM
Abbreviation: DIM
Chemical structure name: 3,3'-diindoylmethane
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