1. An Investigation into the Effects of Diindolylmethane (BioResponse DIM®) Supplementation in Women with Low-Grade Cervical Cytological Abnormalities.
Cancer Research UK
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2. Diindolylmethane in Healthy Volunteers: Multi Dose Study
University of Kansas

3. Diindolylmethane in Treating Patients With Abnormal Cervical Cells
Barts and the London School of Medicine
London, UK

4. Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia
Sponsor: NYU, New York Downtown Hospital
New York, NY

5. An Open Label Pilot Trial of BioResponse-DIM for the Treatment of Anal Human Papillomavirus Infection
Cornell University,
New York, NY

6. Diindolylmethane in Treating Patients With Nonmetastatic Prostate Cancer That Has Not Responded To Previous Hormone Therapy
Barbara Ann Karmanos Cancer Institute, Wayne State University
Detroit, MI

7. Diindolylmethane in Treating Patients Undergoing Surgery for Stage I or Stage II Prostate Cancer
University of Wisconsin
Madison, WI

8. Diindolylmethane in Healthy Nonsmokers
University of Kansas

9. New Therapy of Laryngeal Papilloma in Children
Boston Medical Center

Please visit ClinicalTrials.gov for a listing of Clinical Trials using DIM.

• DIM and Prostate Health: Cell Cycle-Dependent Effects of 3,3'-Diindolylmethane on Proliferation and Apoptosis of Prostate Cancer Cells.
  
  
• DIM and Breast Health: Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells.
  
  
• Benefits of Healthy Estrogen Metabolism: A hormonal association between estrogen metabolism and proliferative thyroid disease.
  
  
• DIM Promotes Immune Function: Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.
  

• Ali S, Banerjee S, Ahmad A, El-Rayes BF, Philip PA, Sarkar FH. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2008 Jun;7(6):1708-19.
  
  
• Azmi AS, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH.Chemoprevention of Pancreatic Cancer: Characterization of Par-4 and its Modulation by 3,3' Diindolylmethane (DIM). Pharm Res. 2008 Apr 22.
  
  
• Kong D, Banerjee S, Huang W, Li Y, Wang Z, Kim HR, Sarkar FH .Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res. 2008 Mar 15;68(6):1927-34.
  
  
• Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Mol Cancer Ther. 2007 Oct;6(10):2757-65.
  
  
• Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, Sarkar FH. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem. 2007 Jul 20;282(29):21542-50.
  
  
• Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 2007 Apr 1;67(7):3310-9.
  
  
• Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, Sarkar FH .Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res. 2006 Oct 15;66(20):10064-72.
  
  
• Zeligs MA, Bradlow HL, Diindolylmethane (DIM), formed from Indole-3-carbinol (I3C), is the dominant anti-proliferative indole in cell culture media after adding I3C. Proc. Am. Assoc. Cancer Res. 2006 Apr; 47 (Abstract #5597).
  
  
• Weber, CA, et al. Oral Treatment of Persistent Plantar Warts with Absorption-enhanced Diindolylmethane, Proceedings of the International Foot and Ankle Congress, Toronto, Canada. May 2005 (Meeting Abstract and Presentation).
  
  
• Zeligs, MA, et al. In vivo, uterine-protective activity of absorption-enhanced diindolylmethane: Animal and preliminary human use in combination with Tamoxifen. Proc Am Assoc Cancer Res. 2003. 44:1268, (Abstract #6347).