Research Abstracts and Clinical Studies -- Diindolylmethane (DIM) and I3C

New Research Abstracts:

DIM and Prostate Health: The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development.
DIM and Breast Health: Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells.
Benefits of Healthy Estrogen Metabolism: Urinary estrogen metabolites in women at high risk for breast cancer.
DIM Promotes Immune Function: Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model.
DIM Inhibits Experimental Cancer: 3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants.

Recent Scientific Investigations:

Ali S, Banerjee S, Ahmad A, El-Rayes BF, Philip PA, Sarkar FH. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2008 Jun;7(6):1708-19.
Azmi AS, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH.Chemoprevention of Pancreatic Cancer: Characterization of Par-4 and its Modulation by 3,3' Diindolylmethane (DIM). Pharm Res. 2008 Apr 22.
Kong D, Banerjee S, Huang W, Li Y, Wang Z, Kim HR, Sarkar FH .Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res. 2008 Mar 15;68(6):1927-34.
Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Mol Cancer Ther. 2007 Oct;6(10):2757-65.
Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, Sarkar FH. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem. 2007 Jul 20;282(29):21542-50.
Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 2007 Apr 1;67(7):3310-9.
Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, Sarkar FH .Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res. 2006 Oct 15;66(20):10064-72.
Zeligs MA, Bradlow HL, Diindolylmethane (DIM), formed from Indole-3-carbinol (I3C), is the dominant anti-proliferative indole in cell culture media after adding I3C. Proc. Am. Assoc. Cancer Res. 2006 Apr; 47 (Abstract #5597).
Weber, CA, et al. Oral Treatment of Persistent Plantar Warts with Absorption-enhanced Diindolylmethane, Proceedings of the International Foot and Ankle Congress, Toronto, Canada. May 2005 (Meeting Abstract and Presentation).
Zeligs, MA, et al. In vivo, uterine-protective activity of absorption-enhanced diindolylmethane: Animal and preliminary human use in combination with Tamoxifen. Proc Am Assoc Cancer Res. 2003. 44:1268, (Abstract #6347).

All Research Abstracts:
Diindolylmethane and I3C

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these sections:

Benefits of Healthy Estrogen Metabolism

DIM Promotes Healthy Estrogen Metabolism

DIM and Breast Health

DIM and Uterine / Cervical Health

DIM and Prostate Health

DIM and Antioxidant Activity

DIM Reduces Cellular Inflammation

DIM Promotes Immune Function

DIM Inhibits Experimental Cancer

DIM Inhibits Human Papilloma Virus (HPV) Growth

DIM is Different than I3C (Indole-3-carbinol)

About Non-DIM Products from I3C

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