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New Research Abstracts: Updated: 07/15/2010


Recent Scientific Investigations:

  • Ali S, Banerjee S, Ahmad A, El-Rayes BF, Philip PA, Sarkar FH. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2008 Jun;7(6):1708-19.

  • Azmi AS, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH.Chemoprevention of Pancreatic Cancer: Characterization of Par-4 and its Modulation by 3,3' Diindolylmethane (DIM). Pharm Res. 2008 Apr 22.

  • Kong D, Banerjee S, Huang W, Li Y, Wang Z, Kim HR, Sarkar FH .Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res. 2008 Mar 15;68(6):1927-34.

  • Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Mol Cancer Ther. 2007 Oct;6(10):2757-65.

  • Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, Sarkar FH. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem. 2007 Jul 20;282(29):21542-50.

  • Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 2007 Apr 1;67(7):3310-9.

  • Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, Sarkar FH .Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res. 2006 Oct 15;66(20):10064-72.

  • Zeligs MA, Bradlow HL, Diindolylmethane (DIM), formed from Indole-3-carbinol (I3C), is the dominant anti-proliferative indole in cell culture media after adding I3C. Proc. Am. Assoc. Cancer Res. 2006 Apr; 47 (Abstract #5597).

  • Weber, CA, et al. Oral Treatment of Persistent Plantar Warts with Absorption-enhanced Diindolylmethane, Proceedings of the International Foot and Ankle Congress, Toronto, Canada. May 2005 (Meeting Abstract and Presentation).

  • Zeligs, MA, et al. In vivo, uterine-protective activity of absorption-enhanced diindolylmethane: Animal and preliminary human use in combination with Tamoxifen. Proc Am Assoc Cancer Res. 2003. 44:1268, (Abstract #6347).

All Research Abstracts:
Diindolylmethane and I3C

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